在这部哥斯拉之世纪必杀阵动作/恐怖/科幻片中,一个全身闪红光的哥斯拉在香港登陆，并把港岛和九龙的繁荣商业区破坏後离去。及後东京海底队道亦因为隧道机械主轴溶化不停发生事故，原来哥斯拉身上的冷却系统已破坏，令牠体内核子分裂快速活性化，并变成一座懂得步行的核子厂。同时东京水族馆发生谜一样的事件—水族馆内的鱼被离奇杀害，经研究後发现是一些生活在二亿多年前的地层生物—狄斯亚所造成。在临海副都心，自卫队派出冷冻战车迎战不明生物—狄斯亚及哥斯拉。此时哥斯拉的体温最终到达一千二百度，并可能引发全人类灭亡的核爆……
Something has destroyed Birth Island, home of Godzilla and Little Godzilla and soon, it is discovered that Godzilla has developed a bright flaming glow, indicating that his nuclear energy is growing out of control. Fearing that Godzilla will soon explode, the G-Force tries to freeze him, thus cooling his temperature. But another problem arises as a horde of human sized creatures, formed from a combination of Godzilla cells, and the weapon that destroyed the original one, The Oxygen Destroyer. Now the military must try to stop these creatures and stop Godzilla from going through a nuclear meltdown that could destroy the world.
