在这部魔鬼刺客动作/剧情/犯罪片中,古巴驻美大使在纽约市，当著古巴军事情报局头子陶瑞纳及其首席副官捐安贝格多的面前遭人刺杀，美国联邦警长麦克陶思的训练师亚历克斯瑞德及中情局中级官员指派他，必须在该名刺客再度杀之前追捕到她，中情局认为那件暗杀是席梦依罗宾蒂所为，她是一名年轻美丽的法国刺客，德恩不这么认为，因席梦依自１９８８年起就未曾再涉入暗杀行动，尽管如此，德恩必须在古／美高峰会议召开前，只有４８小时的时间在布拉客找到席梦依。
The Ambassador of Cuba was killed in New York. To prevent another attack of the terrorists at the US-Cuba-summit in Prague the CIA sends one of their best federal agents, Michael Dane (Dolph Lundgren). The suspected killer Nikita is a lesbian club owner, Simone Rosset. But as usual everything is much more complicated than it seemed at first; and therefore Dane has to work much more with his brain than with his muscles to survive.
