在这部死亡列车动作片中,雷恩为了替伙伴报仇，前往墨西哥追查一群由美国逃离境外的抢匪。这群抢匪在美国抢劫了一批价值九百万美元的钻石，并在逃往墨西哥的途中，在火车上杀了很多无辜的人质。抢匪被逮捕后被遣返美国，但火车在开往美国的途中，抢匪趁机突围掌握了火车操控权，雷恩再度面临重演的历史，这次他要尽力保护车上的人质，度过这次危机。
A man is supposed to guard a shipment of diamonds being sent by rail. But a man robs the train and kills the men guarding the diamonds. The robbers derail the train and hope to get away with their crime. The robbers get caught in Mexico and are sent to prison by rail. The robbers take over the prison train they are on. Will these robbers get away with their crime or will the bodyguard kill all of the robbers and reclaim the train?
