在这部抢钱游戏喜剧片中,蓝尼原本要将一笔巨额款项，从西岸洛杉矶送到东岸纽约，但是路途中却遭人暗算，导致各方人马开始追杀蓝尼，大家尔虞我诈，心怀不轨，都企图要将巨款占为已有。在寻找过程中更是花招百出，意想不到的状况接踵而来，究竟到底是谁拿了这笔钱
Mobster Tony Thick is expecting $5 million in cash to be delivered by Lenny Long from Los Angeles. Lenny is a mule for the mob and he's gone missing with the cash - is he dead? No one knows. When Lenny is a no show, Thick sends Shady to L.A. to look for the missing cash. Shady has no idea of the crazies he's going to run into. Shady meets Lenny's baby-desperate wife Sally, his ditsy mistress Eve, his muscle-headed brother Louis, his quirky neurosurgeon Dr. Hooker and a crew of other nut jobs all looking for the missing cash. When Lenny finally shows up in a San Bernardino Hospital in an on-again/off-again coma everything is turned upside down and everyone is on the chase for their share of the cash.
