在这部印第安追逐记片中,约翰是一名派驻洛杉矶的警察老鸟，他受命前往纳瓦伙印地安保护区逮捕一名命案凶嫌，当他沿着线索骑马横跨沙漠进行追捕时，深入敌方领域的他发现自己反而在一夕间成为被追捕的猎物，唯有奋力一搏，才能换来生存下去的一线生机。
John Cain is a big city cop who journeys deep into the heart of Navajo darkness to catch a brutal killer in this contemporary Western Thriller. A homicide detective on the verge of personal and career burn out, is sent to the Navajo reservation in Arizona to transport a mystic "coyote man" wanted for murder back in Los Angeles, but when the killer escapes from his custody, Cain must track him down across the forbidden Sonoran desert on horseback. Warned of the killer's mythical power to "skinwalk" - Cain is plunged into a deadly confrontation where predator becomes prey - and the quest for justice becomes a battle for his very soul.
