在这部地球上最后一个女人恐怖/科幻片中,Harold Gern,一个最近深陷法律纠纷的纽约商人,正和他那迷人的妻子Evelyn在Puerto Rico享受假期。前来洽谈相关法律事宜、兼Gern的朋友及律师的Martin Joyce和他们一起。Gern没心情谈公事,他邀请Joyce一起潜水。浮出水面时,他们惊奇于自己不用氧气罐就无法呼吸!他们爬上船时发现仆人Manuel死于窒息。由于无法启动引擎,他们合力把船划上岸。40分钟后,他们来到一片丛林,在那里,植物供给的氧气使他们马上可以正常呼吸(并点燃香烟冷静下来)。他们渐渐明白他们或许是这片区域最后的幸存者,甚至可能是这个世界最后的幸存者······
Ev, along with her husband, Harold, and their lawyer friend Martin, are swimming while on vacation in Puerto Rico. When they resurface, they gradually conclude that an unexplained, temporary interruption of oxygen has killed everyone on the island... maybe even the world!