在这部酷狗上学记动画/家庭/喜剧片中,传奇狗肖立志学会说话后并不满足，它希望能够成为一个真正的男孩，在伊万教授的帮助下，通过DNA的转变，肖立志获得了人类的思维和性格……
Leonard is a 4th grader; his mother, Mrs. Mary Lou Helperman, is his teacher, and has been nominated for a teaching award. They plan a trip to Florida for the finals, but need to leave their dog, Spot, behind. Unknown to Mrs. Helperman, Spot has been masquerading as a boy, Scott, who is her star pupil. Spot wants nothing more than to be a real boy, and sees a way to this when mad scientist Ivan Krank appears on the Barry Anger show. Krank thinks he can turn animals into humans. Conveniently, his lab is right down the street from where the Helpermans are staying, so Spot, as Scott (and the rest of his family) convinces Mary Lou to take him along. Spot becomes a man, but discovers it's not everything he ever dreamed of after all.
